Treatment of Malaria
For Uncomplicated Falciparum malaria (Adult >35 kg)
The first line treatment for falciparum malaria is artemether + lumefantrine (AL) given over three days and a single dose primaquine.
- Tab. Artemether and Tab. Lumefantrine (80mg + 480mg)
(6 doses)
STAT-8Hrs- then BD for 2 more days.
- Tab. Primaquine on day 1.
NOTE: Take after a full meal or whole milk. If a patient vomits within 30 minutes of taking a dose, he or she should repeat the dose. Ideally, the first two doses should be taken 8 hours apart.
For Complicated Falciparum Malaria (Severe): Intravenous or intramuscular artesunate for at least 24 h and until the patient can tolerate oral medication. Once a patient has received at least 24h of parenteral therapy and can tolerate oral therapy, complete treatment with full course artemether + lumefantrine (AL).
Inj. Artesunate 2.4 mg/kg STAT, 12 hours and 24hours and then OD until oral medication is tolerated.
If Artemisinin combination therapy is not available and chloroquine sensitive species.
- Plasmodium Vivax and Plasmodium Ovale: Tab. Chloroquine for 3 days and Tab. Primaquine for 14 days
- Plasmodium Malariae: Tab. Chloroquine for 3 days
Dosage Distribution:
Chloroquine- Day 1: chloroquine is given at an initial dose of 10 mg base/kg body weight, Day 2: followed by 10 mg/kg body weight, Day 3: 5 mg/kg body weight.
Primaquine- 0.25 mg/kg body weight per day.
Artemether and Lumefantrine- Total dose of 5-24 mg/kg of artemether and 29-144 mg /kg of lumefantrine.
